• Due to the stereospecific actions

  2020-07-28

  

  Due to the stereospecific actions of 11β-HSDs, metabolizing exclusively 7k25OHC and 7β25OHC, the potent EBI2 ligand 7α25OHC is neither formed nor degraded by these enzymes. Nevertheless, although the 7α-hydroxylated form was found to be preferred over the 7β-hydroxylated metabolite for EBI2 activati

• Despite the important agronomic traits regulated by SUMO

  2020-07-28

  

  Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb

• As the focus of this review is

  2020-07-28

  

  As the focus of this review is DNA synthesis of damaged templates, the example of XP will be detailed. The most prominent symptoms of XP patients affect the skin, where many lesions, including tumors, are frequently observed, but only in regions exposed to the sunlight. Unfortunately, the face is of

• br Dihydroorotate dehydrogenase DHODH catalyzes the conversi

  2020-07-28

  

  Dihydroorotate dehydrogenase (DHODH) catalyzes the conversion of dihydroorotate to orotate, which might be the rate-limiting step in the pyrimidine biosynthesis. Inhibitors of DHODH show immunosuppressant and antiproliferative activity, which is most pronounced on T-cells. Two examples of inhibito

• We show here that Shp binds to

  2020-07-28

  

  We show here that Shp-2 binds to phosphotyrosine-740 in the cytoplasmic domain of DDR1 in a collagen-dependent manner (Figs. 3A and 4A). The peptide sequence ISpYPML neighboring tyrosine 740 matches well with the immuno-receptor tyrosine-based inhibitory motif (ITIM)-consensus sequence [I/V/L]XpYXX[

• Two in vitro reports using lung fibroblasts

  2020-07-28

  

  Two in vitro reports using lung fibroblasts have shown that cell transmigration, using transwell migration experiments, through collagen I-coated inserts is mediated by DDR2 and the DDR2-associated signaling kinases JAK2 and ERK1/2, but not DDR1 [63] and that DDR2 regulates the adhesion of fibroblas

• br Materials and methods br Results

  2020-07-28

  

  Materials and methods Results Discussion Methylation is the main epigenetic modification in humans and changes in methylation patterns play important roles in tumorigenesis and metastasis. The MS-PCR technique enables precise mapping of methylation patterns in CpG islands of genomic DNA. Th

• br Materials and methods br

  2020-07-28

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated Biocytin guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and LTD4[

• Two G protein coupled CRF receptor subtypes

  2020-07-28

  

  Two G-protein coupled CRF receptor subtypes have been identified and designated as CRF and CRF., These receptors are widely distributed throughout the central and peripheral nervous systems. It appears that the CRF receptor subtype plays a significant role in the stress-related response. The hetero

• Alternative splicing is a critical

  2020-07-28

  

  Alternative splicing is a critical part of regulating gene expression; over 90% of the human transcriptome is alternatively spliced [4]. Identifying the role of alternative splicing in the function of multiple biological and disease processes has driven many research initiatives in recent years [5].

• br Results and discussion br Conclusion This study describes

  2020-07-28

  

  Results and discussion Conclusion This study describes the development of a highly sensitive on-sorbent derivatisation technique, using the novel high-surface area CMV devices, to sample methamphetamine vapour. Previous methods for air sampling for methamphetamine such as sampling cassettes ha

• Our work explains the previously enigmatic observation that

  2020-07-28

  

  Our work explains the previously enigmatic observation that the polarized nuclear organization that defines the transition zone is extended greatly in synapsis-defective mutants (Colaiácovo et al., 2003, MacQueen et al., 2002, Phillips et al., 2005). Synapsis is initiated in the transition zone, and

• br Materials and methods br Results

  2020-07-28

  

  Materials and methods Results Discussion In this study, we demonstrated that, at the level of hREECs, blockade of the ETA receptor partially inhibited the effect of NPY on the secretion of ET-1. This suggests that the secreted ET-1 by NPY contributes, in part, to its own secretion via activ

• br Material and methods br

  2020-07-27

  

  Material and methods Results Discussion The results show for the first time that DDRs may be involved in the pathogenic mechanisms of neurodegenerative diseases. We found that DDR1 and DDR2 levels are up-regulated in post-mortem AD and PD brains, suggesting that these receptors play a role

• Any web based literature search shows how the

  2020-07-27

  

  Any web-based literature search shows how the field is rapidly expanding. This is, not in small part, due to the “ENOR initiative” launched by Dr Iuliano and Dr Lizard in 2010 (). The European Network for Oxysterol Research (ENOR), via regular meetings and symposia, has helped moving the field forwa

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