• Considering their good FAAH inhibitory activity

  2022-01-31

  

  Considering their good FAAH inhibitory activity, compounds and have been selected for an in vivo study in a DSS-induced colitis model. Specific Pathogen Free male 7weeks old C57/Bl6 mice received 2.5% DSS in drinking water during 8days. Concomitantly, they were administrated daily intraperitoneall

• There were hub genes identified by WGCNA among which KIBRA

  2022-01-31

  

  There were 11 hub genes identified by WGCNA among which KIBRA was the hub gene of the black module. The bioinformatics method is an effective and powerful tool to analyze mRNA biotin-LC-LC-tyramide profiles and the related pathways. For instance, the lung cancer risk modules that were closely relat

• Studies utilising GPR mice however report

  2022-01-30

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• While a role for YAP TAZ signaling in oligodendrocytes has

  2022-01-30

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these WAY-262611 are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manner. P

• To assess the roles of GPR and

  2022-01-30

  

  To assess the roles of GPR120 and GPR40 in malignant properties of pancreatic cancer cells, we generated GPR120 and GPR40 knockdown (PANC-sh120 and PANC-sh40, respectively) Bikinin from PANC-1 (Fig. 2A). While no difference of cell growth rate between control PANC-RFP cells and PANC-sh120 cells was

• Antibiotic treatment suggests that cancer promoting bacteria

  2022-01-30

  

  Antibiotic treatment suggests that cancer-promoting bacteria arise from the topotecan sale of Grp109a mice. How does the lack of Gpr109a signaling lead to expansion of potentially cancer-promoting bacteria? Is this phenomenon related to improper development of intestinal Treg cells? Biome with cance

• An increased sympathetic tone and the

  2022-01-30

  

  An increased sympathetic tone and the hormone glucagon are the main glucose mobilizing factors [28], [29]. Single-cell transcriptome analysis of human islet cells suggests the expression of Ffar1 not only in β-cells but also in α-cells [30]. Moreover, analysis of rat α-cells indicates that FFAR1 exp

• All data were analyzed using SAS

  2022-01-30

  

  All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica

• GPR which is also known as FFA receptor FFAR or

  2022-01-30

  

  GPR40, which is also known as FFA receptor 1 (FFAR1 or FFA1), was identified as an orphan receptor in the search for novel human galanin receptor (GALR) subtypes in 1997. Using reverse pharmacology approaches measuring calcium transients, GPR40 were deorphanized and characterized as being activated

• The present study was designed to clarify the distribution a

  2022-01-29

  

  The present study was designed to clarify the distribution and the function of the endothelin receptors in the guinea-pig urinary bladder. We found that endothelin-1 produced a clear tonic contraction via both sodium butyrate subtypes, the endothelin ETA and ETB receptor, and that sarafotoxin S6c a

• In plants NO production is one of

  2022-01-29

  

  In plants, NO production is one of the early responses to stress (Tossi, Lamattina, & Cassia, 2009). Usually, NO signal transduction requires the involvement of downstream signaling compounds. We further investigated the effects of cGMP on GSK-3 expression. The data showed that LY83583 (a cGMP inhib

• Two distinct mechanisms have been

  2022-01-29

  

  Two distinct mechanisms have been described for niacin’s macrophage-based actions [21,22]. First, niacin blocks recruitment of macrophages to atherosclerotic lesions. Second, niacin upregulates macrophage ABCA1 and ABCG1, transporters involved in reverse cholesterol transport. Upregulation of choles

• Strengths The primary feature of GPR agonists resides in

  2022-01-29

  

  Strengths The primary feature of GPR119 agonists resides in their dual mechanism of action in regulating blood glucose 1, 2, 3, 15. GPR119 agonists stimulate GLP-1 release from intestinal L 2 nbdg mg as well as glucose-dependent insulin secretion and insulin promoter activity enhancement in pancrea

• The combination of niacin with a

  2022-01-29

  

  The combination of niacin with a selective PGD2 receptor antagonist laropiprant, designed to circumvent the flushing side effect of niacin, has been evaluated in the HPS2-THRIVE study and showed no clinically meaningful benefit when administered in patients on top of statin therapy [41]. Our data su

• br Material and methods br Results Consistent with our

  2022-01-29

  

  Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing BGP-15 in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in the membrane rufflin

15905 records 511/1061 page Previous Next First page 上5页 511512513514515 下5页 Last page