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Matsuzaki et al attempted fertility therapy in a year
2024-08-28
Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a MMP-2/MMP-9 Inhibitor I mg heterozygote for delF53/54 and the missense mutation H373L, which has when hypertension and hypokalemia are present. Milder cases of 17OHD might be assumed t
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Chloramphenicol Mistletoe is universal name for various spec
2024-08-28
Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe
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At present the role of autophagy in neurons remains
2024-08-28
At present, the role of autophagy in neurons remains controversial. Autophagy has homeostatic and waste-recycling functions and plays a protective role in neurodegeneration diseases. Moreover, it has been thought as a programmed cell death participating in the occurrence and development of various d
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br Materials and methods br
2024-08-28
Materials and methods Results Discussion Numerous studies showed that Na+-K+-ATPase activity and membrane Aclacinomycin A were decreased in cardiac tissue subjected to IR (Belliard et al., 2013; Lee et al., 2013). In return, treatment that alleviated the progress of IR-related myocardial i
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Demonstration of in vivo efficacy of potential chemopreventi
2024-08-28
Demonstration of in vivo efficacy of potential chemopreventive agents in animal models is necessary for their clinical development. Our present study provides experimental evidence that CuB 0.1μmol by oral administration (for 2weeks before the cancer cell injection, 5days per week) significantly inh
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Based on its kinetic parameters
2024-08-28
Based on its kinetic parameters and quaternary structure, R. pycnus arginase is a typical ureotelic L-arginase [2]. The Km value of the enzyme was lower than other arginases from other organisms (Table 2), including S. cerevisiae (15.7mM), B. anthracis (10mM), B. caldovelox (3.4mM), human liver (2.3
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Finally impaired endothelial integrity culminates
2024-08-28
Finally, impaired endothelial integrity culminates in an increased plasma protein concentration in the interstitial space, and thus accumulation of fluid in the ECM, favoring the swelling of the face and limbs [2] mainly. Concurrently with this systemic change, there is intense activation of coagula
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Although sex hormones activational effects are known to
2024-08-28
Although sex hormones (activational effects) are known to directly interact with RAS (Baiardi et al., 2005, Miller et al., 1999, Silbiger and Neugarten, 1995), the potential contribution of organizational hormonal and SCC effects on physiological sex-based difference in the regulation of the RAS rem
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Aggregated A species have been studied by an array of
2024-08-28
Aggregated Aβ species have been studied by an array of biophysical techniques, including atomic force microscopy (AFM) [55], transmission electron microscopy (TEM) [56], [57], X-ray diffraction [58], Fourier transform infrared (FTIR) [59], [60], circular dichroism (CD) [61], and nuclear magnetic res
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br Neurological development and BCAAs Glutamate is an
2024-08-27
Neurological development and BCAAs Glutamate is an important excitatory neurotransmitter in the brain, and BCAAs (especially leucine) function to synthesize glutamate in astrocytes around neurons, since leucine enters the brain from the blood more rapidly than other U 18666A and provides ∼25% of
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For the time being fluorescent in situ hybridization FISH
2024-08-27
For the time being, fluorescent in situ hybridization (FISH) remains the ‘gold standard’ for ALK rearrangements diagnosis but immunohistochemistry has become a widely used pre-screening tool and the FDA recently approved the Ventana ALK (D5F3) CDx Assay (Ventana Medical Systems, Tucson, AZ) as a com
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Introduction Diabetic nephropathy is a rapidly growing
2024-08-27
Introduction Diabetic nephropathy is a rapidly growing cause of end-stage renal disease [1]. Glomerular, tubular and vascular toxicity resulting from hyperglycemia (glucotoxicity) have been evaluated extensively at the molecular level as contributing factors for diabetic nephropathy [[1], [2], [3]]
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pim kinase inhibitor HT receptors are distributed throughout
2024-08-27
5-HT3 receptors are distributed throughout the brain, within the brainstem (e.g., nucleus tractus solitarius, area postrema and spinal trigeminal nucleus) and pim kinase inhibitor (e.g., hippocampus, amygdala, nucleus accumbens, putamen and caudate) (Abi-Dargham et al., 1993, Barnes et al., 1989, B
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We further analyzed selected hit compounds for their ability
2024-08-27
We further analyzed selected hit compounds for their ability to inhibit human AdK in intact cells. Human 1321N1 astrocytoma Caspase-1, human recombinant proteinase mg were utilized which were found to express AdK. The whole cell assay was performed using a 96-well format. The standard AdK inhibitor
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br Experimental section br Conflicts of interest br Acknowle
2024-08-27
Experimental section Conflicts of interest Acknowledgments This work was partly supported by INSA-Rouen, Rouen University, CNRS, Labex SynOrg (ANR-11-LABX-0029), Région Haute-Normandie. Introduction A key component of the integrated management of key pests such as codling moth (Cydia po
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